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Hypogonadism and Low Muscle Mass

Hypogonadism and Low Muscle Mass

Hypogonadism and Low Muscle Mass

It has been observed that as men get older, their metabolic processes that are responsible for producing normal testosterone levels becomes inefficient. The resultant effect is decline in the serum testosterone levels. With increasing age, these men begin to experience sign and symptoms of low testosterone such as low sex drive, poor libido, erectile dysfunction, low energy, decreased muscle mass etc.  This condition is also known as hypogonadism.  According to a survey almost two to six million men in US are suffering from hypogonadism.

Testosterone and Muscle Remodeling:

Anabolic hormones such as testosterone are responsible for building muscle mass by converting dietary nutrients to long chain complex proteins that are converted into muscles. Normal serum levels of testosterone serve following functions:

So, it is no surprise why a lot of people in US tend to rely on exogenous sources of testosterone to gain muscle mass in a short span of time.

Why low testosterone levels lead to low muscle mass?

Muscles are dynamic tissues that constantly undergo wear and tear (also known as remodeling) changes as part of normal metabolism. All muscle tissues have androgen receptors that have special affinity for testosterone. When testosterone is released in the system, it binds androgen receptor and facilitates the remodeling of muscle matrix. With loss of testosterone due to hypogonadism, the muscle remodeling processes shut down and muscle degradation begins.

In addition, with decline in testosterone levels due to aging or disease, estrogen overpowers and converts muscle mass into fat. Several research studies have also proved that belly fat secretes aromatase – an enzyme that converts circulating testosterone to estrogen.

Building muscle mass with low testosterone:

If you have low testosterone levels, start with following simple tips to reverse hypogonadism:

Not every case of symptomatic hypogonadism responds to lifestyle modification and dietary management. Some men may need more aggressive measures such as hormone / testosterone replacement therapy. TRT or testosterone replacement therapy aims at restoring normal testosterone levels in the body to achieve optimal basal metabolism and restoration of other biological and reproductive functions.

If you are experiencing symptoms of hypogonadism, speak to your healthcare professional to see what treatment options are right for you.

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